The mitochondrion (plural mitochondria) is a double membrane-bound organelle found in most eukaryotic cells. The word mitochondrion comes from the Greek μίτος, mitos, i.e. "thread", and χονδρίον—, chondrion, i.e. "granule" or "grain-like".
Mitochondria are commonly between 0.75 and 3μm in diameter but vary considerably in size and structure. Unless specifically stained, they are not visible. Mitochondria have been described as "the powerhouse of the cell" because they generate most of the cell's supply of adenosine triphosphate (ATP), used as a source of chemical energy. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth. Mitochondria have been implicated in several human diseases, including mitochondrial disorders, cardiac dysfunction, and heart failure. In 2014, a study including ten children diagnosed with severe autism suggests that autism may be correlated with mitochondrial defects.
The number of mitochondria in a cell can vary widely by organism, tissue, and cell type. For instance, red blood cells have no mitochondria, whereas liver cells can have more than 2000. The organelle is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, the intermembrane space, the inner membrane, and the cristae and matrix. Mitochondrial proteins vary depending on the tissue and the species. In humans, 615 distinct types of protein have been identified from cardiac mitochondria, whereas in rats, 940 proteins have been reported. The mitochondrial proteome is thought to be dynamically regulated. Although most of a cell's DNA is contained in the cell nucleus, the mitochondrion has its own independent genome that shows substantial similarity to bacterial genomes.
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The Laxgibuu or Laxgyibuu (variously spelled) is the name for the Wolf "clan" (phratry) in the language of the Tsimshian nation of British Columbia, Canada, and southeast Alaska. It is considered analogous or identical to identically named clans among the neighboring Gitksan and Nisga'a nations.
The name Laxgibuu derives from gibuu, which means wolf in the Gitxsan and Nisga'a languages. In Tsimshian the word is gibaaw (gyibaaw or gyibaw), but Tsimshians still use the word Laxgibuu for Wolf clan.
The chief crest of the Laxgibuu is the Wolf. Other crests used by some matrilineal house-groups of the Laxgibuu include black bear.
Some Laxgibuu house-groups are related to Wolf clan groups among the Tahltan and Tlingit First Nations to the north. In the case of the Tlingit, the connection is through Tlingit Wolves who migrated south from what is now Alaska to escape inter-clan warfare and settled among the Tsimshian, Gitxsan, and Nisga'a. Descendants of some of these migrants share with their distant Tlingit relatives variants on the "Bear Mother" story which has been well recorded by anthropologists and folklorists. The Kitsumkalum Laxgibuu are one example of a Tsimshian Wolf group who own the right to tell this story.